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. Author manuscript; available in PMC: 2023 Nov 1.
Published in final edited form as: Nat Rev Genet. 2023 Jan 30;24(5):332–344. doi: 10.1038/s41576-022-00569-3

Figure 6. Exposomics and multi-omic responses.

Figure 6.

The exposome is the cumulative measure of environmental influences including the external environment, lifestyle, behavior, and diet and the resulting biological and endogenous processes. The exposome induces biological responses at every level and should be integrated into multi-omic studies. Ultimately, the complex non-linear interactions between the environment and our genome, epigenome, transcriptome, metabolome, and proteome drive the aging process and the pathogenesis of chronic diseases.