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. 2023 Sep 14;55(10):1686–1695. doi: 10.1038/s41588-023-01499-4

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — Meta-analysis of neoantigen burden, clonality and response to anti-PD-1 treatment in clinical trials of MMRd gastric (Kwon trial³⁵, n = 13 patients) and colorectal (Bortolomeazzi trial⁵⁰, n = 16 patients) cancer. a,b, Total clonal (CCF = 0.75–1.0) and subclonal (CCF = 0–0.5) neoantigen burden (a) and subclonal to clonal neoantigen ratio (b) in patients with objective response (OR, partial or complete) versus nonresponse (NR). c–e, PFS of patients in the upper versus lower quartiles of clonal neoantigen burden (c), subclonal neoantigen burden (d) and subclonal to clonal neoantigen ratio (e). Number of patients from each study in upper (high) and lower (low) quartiles is indicated under the plots. The significance in a and b was assessed using Wilcoxon’s rank-sum test and in c–e using Cox’s proportional hazards regression with the clinical trial study as a covariate.

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