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Population pharmacokinetic parameters for cephalexin in rats: reduced (basic) model
| Value | CL (liter/h/kg) | Vc (liter/kg) | CLD (liter/h/kg) | Vss (liter/kg) | Ka (h−1) | F | ςɛ2a | OBJ |
|---|---|---|---|---|---|---|---|---|
| Population mean | ||||||||
| Estimate | 0.694 | 0.386 | 0.347 | 1.4 | 0.200 | 0.90 | 0.027 | 1,141.7 |
| SE | 0.125 | 0.070 | 0.197 | 0.407 | 0.173 | 0.44 | 0.014 | |
| Interindividual variability | ||||||||
| Estimate | 0.416 | 0.872 | 2.14 | 2.41 | ||||
| SE | 0.194 | 0.230 | 1.05 | 1.29 |
Variance of the residual error model (see text).
