TABLE 4.
Population pharmacokinetic parameters for cephalexin in rats: full model
| Value | CL (liter/h/kg)a | CL (liter/h/kg)b | Vc (liter/kg) | CLD (liter/h/kg) | Vss (liter/kg) | Ka (h−1)c | Ka (h−1)d | F | ςɛ2e | OBJ |
|---|---|---|---|---|---|---|---|---|---|---|
| Population mean | ||||||||||
| Estimate | 0.640 | 0.810 | 0.416 | 0.363 | 1.23 | 0.249 | 0.177 | 0.89 | 0.033 | 1,129.0 |
| SE | 0.164 | 0.110 | 0.057 | 0.071 | 0.238 | 0.056 | 0.036 | 0.25 | 0.015 | |
| Interindividual variability | ||||||||||
| Estimate | 0.382 | 0.783 | 2.34 | 2.38 | ||||||
| SE | 0.109 | 0.173 | 0.997 | 1.12 |
a
CL of cephalexin when quinapril and cephalexin were administered via a GT (group 5).
b
CL of cephalexin for groups 1 to 4.
c
Ka of cephalexin given alone.
d
Ka of cephalexin when quinapril was administered via a GT.
e
Variance of the residual error model (see text).