Table 2.

Accuracy of SLN biopsy for detecting nodal disease

Overall accuracy of SLN biopsy
SLN status per patient, n (%)	pN0 (n = 784)	pN0(i+) (n = 25)	pN1(mi) (n = 24)	pN1 (n = 59)	Total (n = 892)
Positive	0	25 (100)	24 (100)	53 (89.3)	102 (11.4)
ITC	0	25 (100)	0	1 (1.7)	26 (2.9)
Micrometastasis	0	0	24 (100)	6 (10.2)	30 (3.4)
Macrometastasis	0	0	0	46 (77.9)	46 (5.2)

SLN accuracy, n (%) (over the patients who received pelvic ± aortic LND)	pN0 (n = 386)	pN0(i+) (n = 13)	pN1(mi) (n = 14)	pN1 (n = 53)	Total (n = 466)
True positive	0	13 (100)	14 (100)	47 (88.7)	74 (15.9)
False negative	0	0	0	6 (11.3)	6 (1.3)
True negative	386 (100)	0	0	0 (0.0)	386 (82.8)
Overall sensitivity: 92.5 % (74/80); overall FNR: 7.5% (6/80)

Assessment of false negative cases
Case	Pelvic mapping	Number of SLN	Tracer	Injection site	Pelvic LND	Aortic LND	Pelvic positive nodes	Aortic positive nodes	Total nodes	Histology	Classification
1	Bilateral pelvic	2	ICG	Cervix	Bilateral	Yes	6	1	14	Serous	False negative
2	Bilateral pelvic	3	ICG	Cervix	Bilateral	Yes	1	1	38	Serous	False negative
3	Unilateral pelvic (right)	1	ICG	Cervix	Bilateral	No	2 (right)	–	5	Endometrioid G3	False negative
4	Bilateral pelvic	2	ICG	Cervix	No	Yes	0	1	5	Endometrioid G2	Isolated aortic metastasis
5	Bilateral pelvic	3	ICG	Cervix	Bilateral	Yes	0	1	21	Serous	Isolated aortic metastasis
6	Unilateral pelvic (right)	1	ICG	Cervix	Unilateral	No	2 (left)	–	8	Serous	Detected by algorithm
Algorithm Sensitivity: 93.7 % (75/80); Algorithm FNR: 6.2% (5/80)

SLN sentinel lymph node, ITC isolated tumor cells, LND lymph node dissection, FNR false negative rate, pN0 pathologic node negative patients, pN0(i+) pathologic isolated tumor cell in SLN, pN1(mi) pathologic micrometastasis in SLN, pN1 pathologic macrometastasis