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. 2023 Oct 9;13:16991. doi: 10.1038/s41598-023-43988-w

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Plasma metabolomics between HR-NB and LIR-NB. (A) Comparison of orthographic projections of HR-NB and LIR-NB in PLS-DA 3D plot in positive mode. (B) Comparison of orthographic projections of HR-NB and LIR-NB in PLS-DA 3D plot in negative mode. (C) Volcano plot of metabolite of HR-NB vs. LIR-NB in positive mode. (D) Volcano plot of metabolite of HR-NB vs. LIR-NB in negative mode. (E) The heatmap shows clear distinction of metabolites between HR-NB and LIR-NB patients in positive mode. (F) The heatmap shows clear distinction of metabolites between HR-NB and LIR-NB patients in negative mode. (MetaboAnalyst 5.0, https://www.metaboanalyst.ca/).