Table 1.
Differential expressed metabolites in HR-NB vs. LIR-NB in positive mode.
| No | Metabolites | Mass-to-charge ratio | Retention Time (min) |
VIP value | Fold change | P value | Regu-lation | ||
|---|---|---|---|---|---|---|---|---|---|
| 1 | PS(18:0/0:0) | 525.3083 | 20.78 | 2.607 | 0.628 | 0.0001 | Down | ||
| 2 | Trimethylammonioacetate | 117.0791 | 2.81 | 1.3698 | 0.849 | 0.021126 | Down | ||
| 3 | 3-(2-Furanyl)-2-propenal | 122.037 | 3.35 | 1.3439 | 0.792 | 0.023772 | Down | ||
| 4 | cis-2-Thujen-4-ol | 152.1191 | 26.12 | 1.3984 | 0.764 | 0.018509 | Down | ||
| 5 | Carnitine | 161.1053 | 2.79 | 1.9086 | 0.767 | 0.0011229 | Down | ||
| 6 | Succinylmonocholine | 203.1159 | 3.31 | 1.6842 | 0.792 | 0.0042874 | Down | ||
| 7 | Pentyl heptanoate | 217.2041 | 8.87 | 1.3124 | 0.748 | 0.027357 | Down | ||
| 8 | Isoamyl p-anisate | 222.12305 | 9.2 | 1.7266 | 0.615 | 0.0033729 | Down | ||
| 9 | Butyl butyryllactate | 238.1182 | 8.49 | 1.5043 | 0.720 | 0.011094 | Down | ||
| 10 | Palmitic amide | 255.2563 | 21.09 | 1.3249 | 0.896 | 0.0427 | Down | ||
| 11 | 3-(L-Menthoxy)-2-methylpropane-1,2-diol | 261.2304 | 8.91 | 1.1789 | 0.827 | 0.048038 | Down | ||
| 12 | C16 Sphinganine | 273.2669 | 10.25 | 1.4175 | 0.851 | 0.009 | Down | ||
| 13 | Stearamide | 283.2876 | 25.49 | 1.7714 | 0.818 | 0.0038 | Down | ||
| 14 | Tetradecyl isobutyrate | 284.2715 | 28.65 | 1.2142 | 0.803 | 0.041598 | Down | ||
| 15 | ( ±)-Octanoylcarnitine | 287.2095 | 9.2 | 1.0738 | 0.740 | 0.0312 | Down | ||
| 16 | Linoleamide | 301.238 | 19.7 | 1.48 | 0.688 | 0.0046 | Down | ||
| 17 | Enigmol | 301.2982 | 11.44 | 1.471 | 0.798 | 0.01308 | Down | ||
| 18 | (E,E)-3,7,11-Trimethyl-2,6,10- dodecatrienyl heptanoate | 334.287 | 20.48 | 1.4235 | 1.725 | 0.0174 | Up | ||
| 19 | Dodecanoylcarnitine | 343.27205 | 10.84 | 1.6161 | 0.602 | 0.0009 | Down | ||
| 20 | Eicosanoyl-EA | 355.3448 | 14.04 | 1.2037 | 0.748 | 0.043433 | Down | ||
| 21 | 11,12-Dimethylrosmanol | 374.2091 | 9.6 | 1.9813 | 0.394 | 0.0006997 | Down | ||
| 22 | Lys Thr Ile Glu | 511.25995 | 9.42 | 1.7111 | 0.547 | 0.0036836 | Down | ||
| 23 | PC(18:3(6Z,9Z,12Z)/0:0) | 517.3162 | 12.06 | 1.4293 | 1.773 | 0.033 | Up | ||
| 24 | LysoPC(18:2(9Z,12Z)) | 519.33215 | 12.86 | 2.0851 | 0.822 | 0.000344 | Down | ||
| 25 | LysoPC(18:1(11Z)) | 521.3478 | 14.4 | 1.6576 | 0.847 | 0.0065 | Down | ||
| 26 | LysoPC(0:0/18:0) | 523.3635 | 16.44 | 1.3481 | 0.891 | 0.023323 | Down | ||
| 27 |
LysoPC(22:6(4Z,7Z, 10Z,13Z,16Z,19Z)) |
567.3319 | 12.82 | 1.4776 | 0.763 | 0.012665 | Down | ||
| 28 |
PA(18:4(6Z,9Z,12Z, 15Z)/13:0) |
626.3955 | 20.09 | 1.4303 | 0.706 | 0.015919 | Down | ||
| 29 |
DG(14:1(9Z)/22:3 (10Z,13Z,16Z)/0:0)[iso2] |
638.4879 | 38.39 | 1.6086 | 0.549 | 0.0083 | Down | ||
| 30 | SM(d18:2/14:0) | 672.5197 | 26.36 | 2.1955 | 0.424 | < 0.0001 | Down | ||
| 31 | SM(d16:1/16:0) | 674.5355 | 29.47 | 2.4822 | 0.408 | < 0.0001 | Down | ||