TABLE 1.
Effects of sparfloxacin on joint cartilage in juvenile ratsa
| Dose (mg/kg) | No. of doses per day | Duration of treatment (days) | Incidence of lesions in knee joint cartilageb |
|---|---|---|---|
| 600 | 1 | 1 | 0/6 |
| 600 | 1 | 4 | 0/10c |
| 600 | 1 | 8 | 0/10 |
| 600 | 2 | 1 | 0/6 |
| 1,800 | 1 | 1 | 5/8d |
a
All doses were administered orally. The rats were investigated 3 days after administration of the last dose.
b
Values are number of rats with lesions in knee joint cartilage/number of rats studied.
c
Rats from this group were studied 7 months after dosing.
d
All cartilage lesions were located in the femoral part of the knee joint (ventral).