Figure 3.

Gestational age strongly affects the amniotic fluid proteome. Principal component analysis was performed for human and rhesus datasets separately and then PC1 was plotted against PC2 for both species together, and against rhesus equivalent gestational age windows for each species separately (a). For human amniotic fluid (b) and rhesus (c), the differential abundances associated with longitudinal gestational age (measured in actual days) are shown in volcano plots with the log2 transformed fold change on the x-axis and the – log10Pvalue on the y-axis. Red indicates increased abundance with gestational age, and blue is decreased.