Fig. 2. Simulation studies with multiple eQTL SNPs per gene.

a Type I error and power and b precision–recall curves for differential ASE detection along a continuous variable observed in simulations. Allele-specific read counts are simulated from beta-binomial mixture model assuming multiple eQTLs drives ASE of a transcribed SNP (tSNP). We assume no linkage disequilibrium among the eQTLs and between the eQTLs and the tSNP. The sample size (number of individuals) is varied N = 10, 50, 100. Source data are provided as a Source Data file.