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. 2023 Oct 9;14:6317. doi: 10.1038/s41467-023-42016-9

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — UMAP colored by a cell type, b disease status. c Genes that show differential ASE between type 2 diabetes and controls in pancreatic endocrine cell types identified by DAESC-BB (FDR < 0.05, likelihood ratio test, two-sided) and distribution of allelic fraction in each donor. Alt: alternative allele read count; total: total allele-specific read count. P values in subgraph titles are original P values without multiple comparison adjustment. Source data are provided as a Source Data file.