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. 2023 Sep 26;14:1268939. doi: 10.3389/fimmu.2023.1268939

Figure 1.

Figure 1

Spectrums of tumor associated macrophages. Tumor associated macrophages (TAMs) can develop from monocytes, monocyte-derived alveolar macrophages (MoAMs), tissue-resident alveolar macrophages (TRAMs), or interstitial macrophages (IMs) in the lung. TAMs exist as a spectrum of phenotypes from inflammatory to anti-inflammatory cells. Inflammatory macrophages are defined by higher expression of antigen-presenting and co-stimulatory molecules including CD80/CD86, CD40, MHCII, and secretion of inflammatory cytokines, whereas anti-inflammatory macrophages are immunosuppressive, expressing CD163 and Dectin-1, higher levels of CD206, and secretion of immunosuppressive cytokines and angiogenic factors. Typically, anti-inflammatory TAMs are more abundant in NSCLC.