Table 1A.
Top performing biomarker panels curated by RSBMR.
| Assortment/ Braak Stage cut-off | Panel.Size | Genes | R.Squared | Adjusted.R.Square | Validation.Error | AUC (Mean) | Sensitivity (Mean) | Specificity (Mean) | Intercept | Features' weighing factors |
Features' Expression valuesin in log base 2 |
||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Gene1 | Gene2 | Gene3 | Gene4 | Gene5 | Gene6 | Gene7 | Gene8 | Gene1 | Gene2 | Gene3 | Gene4 | Gene5 | Gene6 | Gene7 | Gene8 | ||||||||||
| Assortment 1/ Braak I | 4 | CRH,DLEC1,GSTT1,HBD | 0.48 | 0.44 | 0.14 | 0.95 | 0.92 | 0.85 | -6.67 | 1.93 | -0.75 | -0.36 | 0.64 | -0.105 | -0.184 | 0.2182 | 0.062 | ||||||||
| Assortment 2/ Braak II | 8 | CRH,DDX3Y,HBB,HBD,RPS4Y2,TSIX,USP9Y,VGF | 0.48 | 0.4 | 0.19 | 0.91 | 0.93 | 0.8 | 19.27 | -1.24 | 1.51 | -0.19 | -2.34 | -0.61 | -1.16 | 1.95 | 0.34 | -0.105 | -0.309 | -0.04 | 0.063 | -0.091 | -0.029 | 0.013 | 0.24 |
| Assortment 3/ Braak III | 8 | C4B,CARTPT,DDX3Y,HBB,HBD,RPS4Y2,TSIX,USP9Y | 0.79 | 0.75 | 0.18 | 0.93 | 0.96 | 0.74 | -85.43 | -3.06 | 5.42 | -9.81 | 10.97 | -13.76 | 13.46 | 1.02 | 5.43 | 0.003 | -0.04 | -0.309 | -0.04 | 0.063 | -0.091 | -0.029 | 0.013 |