Table 1B.
Top performing biomarker panels curated by k-fold.
| Assortment/ Braak Stage cut-off | Panel.Size | Genes | R.Squared | Adjusted.R.Square | Validation.Error | AUC | Sensitivity | Specificity | Intercept | Features' weighing factors |
Features' Expression values in log base 2 |
||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Gene1 | Gene2 | Gene3 | Gene4 | Gene5 | Gene6 | Gene7 | Gene8 | Gene9 | Gene10 | Gene1 | Gene2 | Gene3 | Gene4 | Gene5 | Gene6 | Gene7 | Gene8 | Gene9 | Gene10 | ||||||||||
| Assortment 1/ Braak I | 4 | DLEC1,GSTT1,HBB,HBD | 0.51 | 0.47 | 0.12 | 0.84 | 0.91 | 0.76 | -21.28 | 2.48 | -4.99 | 0.56 | 4.26 | -0.184 | 0.218 | -0.04 | 0.063 | ||||||||||||
| Assortment 2/ Braak II | 3 | HBB,SLC47A2,VGF | 0.5 | 0.47 | 0.13 | 0.83 | 0.81 | 0.86 | 22.42 | -0.83 | -1.26 | 1.08 | -0.04 | -0.024 | 0.24 | ||||||||||||||
| Assortment 3/ Braak III | 10 | C4B,CARTPT,DDX3Y,HBB,HBD,RPS4Y1,RPS4Y2,TSIX,USP9Y,XIST | 1 | 1 | 0.22 | 0.9 | 0.88 | 0.91 | -3191.51 | 185.87 | -66.68 | 259.3 | -320.64 | 63.84 | -484.2 | -146.26 | 419.78 | 409.83 | 122.79 | 0.003 | -0.04 | -0.309 | -0.04 | 0.063 | 0.052 | -0.091 | -0.029 | 0.013 | -0.056 |