TABLE 3.
In vivo efficacy of disulfiram
| Expt no. | Drug (dosage)a | Treated mice
|
Control mice
|
||
|---|---|---|---|---|---|
| No. cured/total no. (P value) | No. of trophozoites/high-power field (P value) | No. cured/total no. | No. of trophozoites/high-power field | ||
| 1 | Disulfiram (25 mg q.d., 4 days) | 4/10 (0.003) | 2.87 ± 7.85 (0.049) | 0/10 | 6.74 ± 9.30 |
| 2 | Disulfiram (25 mg, q.d., 5 days) | 3/14 (0.082) | 5.23 ± 7.33 (0.011) | 1/10 | 13.16 ± 6.78 |
| Metronidazole (5 mg, q.d., 5 days) | 15/15 | 0 | 1/10 | 13.16 ± 6.78 | |
| 3 | Disulfiram (25 mg, b.i.d., 4 days) | 4/10 (0.003) | 2.03 ± 3.12 (<0.001) | 0/10 | 78.20 ± 28.69 |
a
q.d., every day; b.i.d., twice a day.