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. 2023 Sep 26;15:1223911. doi: 10.3389/fnagi.2023.1223911

Figure 3.

Figure 3

Neuronal Htt-PQ72 decreases climbing muscle performance with age. (A) Negative geotaxis assay demonstrates progressive loss of climbing muscle performance in Elav(II) > Htt-PQ72 flies beginning at P21 (ANOVA for all, P7: F(3,56) = 1.2, p = 0.31, n = 12–19 cohorts per group; P14: F(3,27) = 2.9, p = 0.06, n = 6–9 cohorts per group; P21: F(3,50) = 3.2, p = 0.03, n = 11–15 cohorts per group; P28: F(3,46) = 5.6, p = 0.002, n = 9–15 cohorts per group. All: Dunnett’s post hoc *p < 0.05 and **p < 0.01 compared to GFP). (B) Flight index assay demonstrates no significant difference in flight muscle performance in Elav(II)-driven flies at P28 (ANOVA F(2,7) = 2.2, p = 0.19, n = 3–4 cohorts with N = 14–19 flies per group). (C) Flight index assay demonstrates no significant difference in flight muscle performance in Elav(X)-driven flies at P21 (ANOVA F(2,10) = 1.5, p = 0.29, n = 3–5 cohorts with N = 11–35 flies per group). All: Data displayed as mean ± SEM.