TABLE 4.

Genes involved in intestinal EMT and their non-coding RNA (ncRNA) regulators in IBD. The symbol “/” indicates treatment. Bone morphogenic protein-7 (BMP7), E-cadherin (CDH1), N-cadherin (CDH2), Crohn’s disease (CD); Dextran sodium sulfate (DSS); Epithelial Growth factor (EGF); Fibroblast growth factor (FGF); Intestinal epithelial cell (IEC); Serine/arginine-rich splicing factor 1 (SRSF1); Transforming growth factor (TGF); Trinitrobenzene sulfonic acid (TNBS); Zinc-finger E-box-binding (ZEB).

ncRNA	Target	Type of study		Effect in EMT		References
miR-200	ZEB1/SMAD2	In vitro Human	IEC6/TGFβ1 IBD: ↓ miR-200b	↓	↑CDH1 ↓Vimentin	Chen et al. (2012), Chen et al. (2013), Zidar et al. (2016)
miR-199a and miR-34a	AXL	Human	IBD: ↓ miR-199a and miR-34a	↓	↓ZEB2, SNAIL1	Mudduluru et al. (2011), Cho et al. (2016), Boros et al. (2017), Boros et al. (2018)
miR-155-5p, miR-146a-3p, miR-213p	CDH1	Human	CD: ↑miR-146a3p, miR-155-5p and miR-213p	↑	↓CDH1	Guz et al. (2020)
Circ_0001666	SRSF1/BMP7	In vitro Human	IEC/TGFβ1 CD: ↑ Circ_0001666	↑	↓CDH1 ↑Vimentin, SNAIL, CDH2	Li et al. (2023)