Fig. 9.
Female Balb/c mice were infected with HRSV line 19 (5 × 106 PFU) by intranasal instillation, concomitant with different doses of compounds 1 and 2 in DMSO 90%, Dexamethasone (DEX) and Ribavirin (RBV) by i.p. injection on day 0. On days 1–4, all mice received further inoculations of compounds 1 and 2, DEX and RBV i.p. The animals were killed on day 4 and the lungs were used for titration of infectious virus. Data show mean ± SD from n = 6 mice/condition, for compounds 1 and 2, and 3 mice/condition for RBV and DEX.. *Significantly different from HRSV infected mice (p-value<0.05), ANOVA. Saline solution: infected animals, treated with saline solution by i.p. injection. DMSO 90%: infected animals, treated with DMSO 90% by i.p. inyection.