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. 2023 Sep 9;26(10):107831. doi: 10.1016/j.isci.2023.107831

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© 2023 The Authors

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

PMC Copyright notice

Transcriptional profiling of SMoM2-Kmt2d^Cf/Cf primary and metastatic tumors compared to SmoM2 reveals upregulation of genes/pathways associated with aggressive cancer

(A) Heatmap analysis of bulk RNA-seq showing differentially expressed genes between SmoM2-Kmt2d^Cf/Cf primary and metastatic tumors. (p <= 0.05; FC >= 1.5). See also Table S7.

(B) Heatmap analysis of bulk RNA-seq showing differentially expressed genes between SmoM2 primary tumors and SmoM2-Kmt2d^Cf/Cf primary and metastatic tumors. (p <= 0.05; FC >= 1.5). See also Table S8.

(C) Network enrichment analysis of genes upregulated in SmoM2-Kmt2d^Cf/Cf primary and metastatic tumors compared to SmoM2 primary tumors. Also see Figure S8.