Table 1.
Results of Multivariable Regression Models Including Both DNAm GrimAge and MetaboHealth as Exposures and Frailty Measures as Outcome
| DNAm GrimAge | MetaboHealth | ||||
|---|---|---|---|---|---|
| Adjusted* Beta Per SD (CI) | pFDR | Adjusted* Beta Per SD (CI) | pFDR | ||
| FI | n = 1 339 | 0.08 (0.03; 0.14) | .02 | 0.17 (0.11; 0.22) | 7.35 × 10−9 |
| FP | n = 1 339 | 0.01 (-0.05; 0.07) | .79 | 0.11 (0.05; 0.17) | 5.51 × 10−4 |
| CFP | n = 748 | 0.11 (0.03; 0.19) | .02 | 0.10 (0.02; 0.17) | .02 |
| TFI | n = 1 339 | 0.07 (0.01; 0.13) | .06 | 0.11 (0.06; 0.17) | 3.38 × 10−4 |
| MPI | n = 1 344 | 0.15 (0.10; 0.21) | 6.06 × 10−6 | 0.17 (0.12; 0.22) | 8.08 × 10−9 |
Notes: CFP = continuous frailty phenotype; CI = confidence interval; FI = frailty index; FP = frailty phenotype; MPI = multidimensional prognostic index; n = number of participants for whom we have information on this frailty score; pFDR = p value after adjustment for multiple testing by the false discovery rate method; SD = standard deviation; TFI = Tilburg Frailty Indicator.
*Adjusted for chronological age at blood sampling, sex, body mass index, cell counts, subcohort, and visit and cohort within the Rotterdam Study.