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. 2023 Oct 9;177(12):1276–1284. doi: 10.1001/jamapediatrics.2023.4038

Table. Network Meta-Analyses of the Association Between Exercise and Insulin Resistance Markers in Children and Adolescents With Excess Weighta.

Marker Aerobic Resistance Concurrent HIIT HIIT/resistance
Fasting glucose (mg/dL)
Resistance −0.55 (−2.86 to 1.77)
Concurrent −1.26 (−3.48 to 0.77) 0.71 (−1.94 to 3.68)
HIIT 0.16 (−2.16 to 2.64) −0.72 (−3.92 to 2.46) 1.42 (−1.57 to 4.48)
HIIT/resistance −3.54 (−7.37 to 0.25) 2.99 (−1.21 to 7.13) −2.28 (−6.06 to 1.77) −3.70 (−7.84 to 0.51)
Control −1.49 (−2.73 to −0.39)b −2.04 (−4.30 to 0.21) −2.75 (−4.95 to −0.79)b −1.32 (−3.71 to 0.96) −5.02 (−8.71 to −1.34)b
Fasting insulin (μU/mL)
Resistance −0.58 (−2.98 to 1.61)
Concurrent −1.28 (−3.47 to 0.72) 0.70 (−2.03 to 3.28)
HIIT 0.29 (−2.04 to 2.53) −0.86 (−3.90 to 2.21) 1.56 (−1.28 to 4.59)
HIIT/resistance −3.64 (−7.28 to −0.02)b 3.06 (−1.08 to 7.13) −2.37 (−5.97 to 1.46) −3.93 (−7.72 to 0.15)
Control −1.48 (−2.72 to −0.32)b −2.05 (−4.37 to 0.13) −2.75 (−4.90 to −0.79)b −1.19 (−3.58 to −1.09) −5.12 (−8.83 to −1.54)b
HOMA-IR
Resistance 0.18 (−1.20 to 1.51)
Concurrent −0.33 (−0.96 to 0.28) 0.50 (−0.87 to 1.84)
HIIT −0.19 (−0.93 to 0.54) 0.37 (−1.12 to 1.78) 0.14 (−0.74 to 0.99)
HIIT/resistance −0.51 (−1.42 to 0.46) 0.69 (−0.89 to 2.23) −0.18 (−1.06 to 0.80) −0.32 (−1.34 to 0.72)
Control −0.71 (−1.20 to −0.24)b −0.53 (−1.84 to 0.72) −1.03 (−1.57 to −0.52)b −0.90 (−1.62 to −0.22)b −1.22 (−2.04 to −0.36)b

Abbreviations: HIIT, high-intensity interval training; HIIT/resistance, combination HIIT and resistance training; HOMA-IR, homeostasis model assessment of insulin resistance; MD, mean difference.

a

Data are expressed as the MD (95% CI). Comparisons should be read from left to right. Values correspond to differences in MDs (95% CIs) between column and row; for positive values, the exercise protocol indicated in the column is favored (eg, aerobic training had a mean fasting glucose loss of 0.55 mg/dL compared with resistance training).

b

P < .05.