Table 2.
Adjusted hazard ratio and incidence rate per 1000 person–years (95% CI) for CVD events and all- cause mortality in CVD primary and secondary prevention cohorts
| Outcome | CVD primary prevention cohort | CVD secondary prevention cohort | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| ADR group, N = 3098 | Control group, N = 3098 | ADR group, N = 7119 | Control group, N = 7119 | |||||||
| Event, n (%) | Incidence rate (95% CI) | Event, n (%) | Incidence rate (95% CI) | aHR (95% CI) | Event, n (%) | Incidence rate (95% CI) | Event, n (%) | Incidence rate (95% CI) | aHR (95% CI) | |
| Primary outcome | ||||||||||
| Composite CVD events | 366 (11.81) | 17.46 (15.76 to 19.34) | 282 (9.10) | 14.27 (12.70 to 16.04) | 1.22 (1.05 to 1.43) | 1574 (22.11) | 46.07 (43.85 to 48.41) | 1431 (20.10) | 41.12 (39.05 to 43.31) | 1.13 (1.05 to 1.21) |
| Myocardial infarction | 140 (4.52) | 6.43 (5.44 to 7.58) | 98 (3.16) | 4.81 (3.95 to 5.86) | 1.33 (1.03 to 1.72) | 667 (9.37) | 17.78 (16.42 to 19.26) | 510 (7.16) | 12.62 (11.49 to 13.86) | 1.32 (1.18 to 1.48) |
| Stroke/TIA | 250 (8.07) | 11.71 (10.34 to 13.26) | 198 (6.39) | 9.85 (8.57 to 11.32) | 1.19 (0.98 to 1.43) | 1041 (14.62) | 28.87 (27.17 to 30.68) | 1016 (14.27) | 28.13 (26.45 to 29.91) | 1.04 (0.95 to 1.13) |
| Secondary outcome | ||||||||||
| All-cause mortality | 659 (21.27) | 29.65 (27.47 to 32.00) | 537 (17.33) | 25.90 (23.80 to 28.19) | 1.14 (1.01 to 1.27) | 2792 (39.22) | 69.53 (67.00 to 72.16) | 2416 (33.94) | 60.38 (58.02 to 62.84) | 1.15 (1.09 to 1.21) |
ADR = adverse drug reaction. aHR = adjusted hazard ratio. CVD = cardiovascular disease. TIA = transient ischaemic attack.