. 2023 Sep 26;370:fnad097. doi: 10.1093/femsle/fnad097

Table 2.

Prediction of extended-spectrum BlaEC enzymes.

Original amino acids	Amino acid change	Positions (according to publications and SANC scheme)	Putative extended-spectrum BlaEC variants
S	N^a	287^{^a}	7, 27, 595, 861, 1814
	C^{^a}		10, 146, 1638, 1922
	G		1046
	I		1237
	R		338, 1236, 1344, 1495
	Deletion		2^c
H/R	P^a	296^a	9, 195, 877
	A		28, 31
	C		1634
	G		1728
	Q		806
	S		40, 43, 44, 47, 49, 60, 75, 117, 132, 140, 142, 155, 298, 438, 473–475, 489
	Y		893
V	L^{^a}	298^a	8
V	A	350^a	585, 1188
	D		571, 1558, 1719, 1790, 1792
	F^a		11, 12
	G		1716
	I		25, 584, 1189, 1889
GSD	GSD deletion^b	286–288^{^b}	2^c

Amino acids highlighted in bold extend the hydrolysis spectrum to include ceftazidime and cefepime according to ^aMammeri et al. (2006) and ^bDoi et al. (2004). ^cThe same BlaEC variant. SANC (structural alignment-based numbering of class C beta-lactamases).