Table 1.
Baseline Characteristics of Study Sample in Multi-Ethnic Study of Atherosclerosis and Osteoporotic Fractures in Men Study
| Variable | MESA (N = 1,973) | MrOS (N = 2,627) |
|---|---|---|
| n (%) or Median [IQR] | n (%) or Median [IQR] | |
| Demographics | ||
| Age, yr | 67 [61–75] | 76 [72–80] |
| Sex, male, n (%) | 917 (46.4%) | 2,627 (100%) |
| Race/ethnicity | ||
| Non-Hispanic White, n (%) | 720 (36.5%) | 2,383 (90.7%) |
| Chinese, n (%) | 237 (12.0%) | 76 (2.9%) |
| Black, n (%) | 543 (27.5%) | 92 (3.5%) |
| Hispanic/Latino, n (%) | 473 (23.9%) | 48 (1.8%) |
| Other, n (%) | — | 28 (1%) |
| BMI, kg/m2 | 27.9 [24.7–31.8] | 27 [25.0–29.0] |
| Hip circumference, cm | 103.5 [97.2–112.0] | 102 [97.0–107] |
| Body surface area, m2 | 1.8 [1.7–2.0] | — |
| Smoking status | ||
| Never smoker, n (%) | 933 (47.2%) | 1,054 (40.1%) |
| Former smoker, n (%) | 902 (45.7%) | 1,525 (58.0%) |
| Current smoker, n (%) | 138 (7.0%) | 48 (1.8%) |
| Comorbidities | ||
| Hypertension, n (%) | 1,118 (56.6%) | 1,303 (49.8%) |
| Diabetes, n (%) | 218 (11.0%) | 358 (13.3%) |
| COPD, n (%) | 33 (1.7%) | 134 (5.1%) |
| Sleep characteristics | ||
| TST, min | 369 [315–417] | 361 [317–401] |
| Time in REM, % | 18.4 [13.9–22.5] | 19.6 [14.7–23.8] |
| Time in supine position, % | 35.1 [12.9–64.2] | 30.2 [11.2–57.6] |
| AHI, events/h | 17.7 [9.4–32.7] | 13 [6.0–24.0] |
| AHI4, events/h | 8.3 [2.9–18.9] | 8.0 [3.0–12.6] |
| % Sleep time <90% SpO2 | 0.62 [0.05–3.37] | 1.0 [0.0–4.0] |
| Baseline SpO2, %* | 96 [95–97] | 95 [94.6–96.8] |
| Ventilatory burden, % eupnea* min/h | 318 [174–619] | 457 [241–839] |
| Hypoxic burden, % min/h | 37.5 [19.2–73.0] | 43.8 [24.0–77.0] |
| Arousal burden, % | 7.2 [5.1–10.2] | 7.5 [5.6–10.0] |
| ESS score | 5.0 [3.0–8.0] | 6.0 [3.0–8.0] |
Definition of abbreviations: AHI = apnea–hypopnea index based on 3% drop in SpO2 or arousal; AHI4 = apnea–hypopnea index based on 4% drop in SpO2; BMI = body mass index; COPD = chronic obstructive pulmonary disease; ESS = Epworth Sleepiness scale; MESA = Multi-Ethnic Study of Atherosclerosis; MrOS = Osteoporotic Fractures in Men Study; SpO2 = oxygen saturation as measured by pulse oximetry; TST = total sleep time.
*
Baseline SpO2 was defined as wakefulness SpO2 in MESA and preevent SpO2 in MrOS.