Table 3.

Associations of Hypoxic Burden, Ventilatory Burden, and Arousal Burden with Incident Cardiovascular Disease, Cardiovascular Mortality, and All-Cause Mortality in Osteoporotic Fractures in Men Study Cohort

	Model 1 (HR [95% CI])	Model 2 (HR [95% CI])	Model 3 (HR [95% CI])	Model 4 (HR [95% CI])
Hypoxic burden
Incident CVD (n = 1,518)	1.12 [1.01, 1.25] *	1.12 [1.01, 1.24] *	1.12 [1.00, 1.24] *	1.13 [1.02, 1.26] *
Cardiovascular death (n = 2,627)	1.24 [1.12, 1.38] †	1.23 [1.11, 1.37] †	1.24 [1.11, 1.37] †	1.22 [1.10, 1.35] †
All-cause mortality, (n = 2,627)	1.06 [1.00, 1.13] *	1.06 [1.00, 1.13] *	1.06 [1.01, 1.13] *	1.06 [1.00, 1.12]‡
Ventilatory burden
Incident CVD (n = 1,518)	1.12 [1.01, 1.24] *	1.12 [1.01, 1.25] *	1.13 [1.01, 1.25] *	1.12 [1.01, 1.25] *
Cardiovascular death (n = 2,627)	1.16 [1.05, 1.28] §	1.16 [1.05, 1.28] §	1.16 [1.05, 1.28] §	1.21 [1.09, 1.35] †
All-cause mortality (n = 2,627)	1.03 [0.98, 1.10]	1.04 [0.98, 1.10]	1.04 [0.98, 1.10]	1.05 [0.99, 1.12]‡
Arousal burden
Incident CVD (n = 1,483)	1.07 [0.96, 1.18]	1.06 [0.96, 1.18]	1.06 [0.96, 1.18]	—
Cardiovascular death (n =2,564)	1.12 [1.01, 1.24] *	1.11 [1.00, 1.23] *	1.11 [1.00, 1.23] *	—
All-cause mortality (n = 2,564)	0.99 [0.94, 1.05]	0.98 [0.93,1.04]	0.98 [0.93, 1.04]	—

Definition of abbreviations: CI = confidence interval; CVD = cardiovascular disease; HR = hazard ratio per 1-SD increase in hypoxic burden, ventilatory burden, and arousal burden.

Statistical significance is highlighted in bold.

Model 1: age + race + body mass index.

Model 2: Model 1 + hypertension + diabetes + smoking status + chronic obstructive pulmonary disease.

Model 3: Model 2 + preevent oxygen saturation as measured by pulse oximetry.

Model 4: Model 3 + desaturation sensitivity (defined as hypoxic burden/ventilatory burden).

^*P < 0.05.

^† P < 0.001.

^‡ P < 0.1.

^§ P < 0.01.