Table 4.
Linear Model between Sleep Apnea–Specific Hypoxic Burden across Ventilatory Burden, Age, Sex, Race, Body Mass Index, Supine Position, FVC, and Waist Circumference in Multi-Ethnic Study of Atherosclerosis Cohort
| Model 1 (n = 1,973) |
R 2 | Model 2 (n = 1,973) |
R 2 | Model 3 (n = 1,973) |
R 2 | Model 4 (n = 1,851) |
R 2 | Model 5 (n = 1,433) |
R 2 | |
|---|---|---|---|---|---|---|---|---|---|---|
| Ventilatory burden (per 1 SD) | 0.88 (0.86, 0.90) * | 0.78 | 0.85 (0.83, 0.87) * | 0.74 | 0.84 (0.82, 0.86) * | 0.73 | 0.85 (0.83, 0.87) * | 0.74 | 0.84 (0.82, 0.87) * | 0.73 |
| Age (per 1 SD) | 0.02 (−0.00, 0.04) | 0 | 0.01 (−0.01, 0.03) | 0 | −0.00 (−0.02, 0.02) | 0 | 0.01 (−0.02, 0.03) | 0 | ||
| Sex (male vs. female) | 0.02 (−0.02, 0.06) | 0 | 0.01 (−0.04, 0.05) | 0 | −0.05 (−0.09, −0.00) † | 0 | 0.06 (−0.01, 0.13) | 0 | ||
| Race | 0.01 | 0.01 | 0 | 0.02 | ||||||
| Black vs. White | −0.11 (−0.16, −0.06) * | −0.10 (−0.15, −0.04) * | −0.08 (−0.13, −0.03) ‡ | −0.17 (−0.24, −0.10) * | ||||||
| Chinese vs. White | −0.02 (−0.09, 0.05) | −0.02 (−0.09, 0.05) | −0.02 (−0.09, 0.05) | −0.09 (−0.17, −0.01) † | ||||||
| Hispanic vs. White | −0.02 (−0.07, 0.04) | −0.00 (−0.05, 0.05) | 0.01 (−0.04, 0.07) | −0.07 (−0.14, −0.01) † | ||||||
| BMI (per 1 SD) | 0.14 (0.12, 0.16) * | 0.07 | 0.13 (0.11, 0.15) * | 0.06 | 0.13 (0.11, 0.16) * | 0.06 | ||||
| Supine position (per 1 SD) | 0.03 (0.01, 0.05) ‡ | 0 | 0.03 (0.01, 0.05) ‡ | 0 | 0.03 (0.01, 0.05) † | 0 | ||||
| Wake SpO2 (per 1 SD) | −0.06 (−0.08, −0.04) * | 0.01 | −0.06 (−0.08, −0.04) * | 0.02 | −0.06 (−0.08, −0.04) * | 0.02 | ||||
| Waist circumference (per 1 SD) | 0.12 (0.09, 0.14) * | 0.05 | ||||||||
| FVC (per 1 SD) | −0.05 (−0.09, −0.01) † | 0 | ||||||||
| Model R2 | 0.78 | 0.80 | 0.80 | 0.80 | 0.80 |
Definition of abbreviations: BMI = body mass index; SpO2 = oxygen saturation as measured by pulse oximetry.
Hypoxic burden was standardized (per 1 SD).
Statistical significance is highlighted in bold.
*
P < 0.001.
†
P < 0.05.
‡
P < 0.01.