Table 1.

Characteristics of studies about D-dimer included in the analysis

No	Author	Year	Sample	Disease	Biomarker	AUC	Sen	Spe	Youden index	No. Case	No. Control	Cut-off value (ng/mL)	References
1	Forrer	2021	Plasma	AAD	D-dimer	0.7600	0.9700	0.3800	0.3500	34	150	300	[22]
2	Yang	2020	Plasma	TAD	D-dimer	0.8770	0.9850	0.6670	0.6520	78	72	NP	[23]
3	Wang	2018	Plasma	AAD	D-dimer	0.9100	0.8800	0.9400	0.8200	144	219	NP	[25]
4	Dong	2017	Plasma	AAD	D-dimer	0.6470	0.8110	0.4750	0.2860	37	40	NP	[26]
5	Li	2017	Plasma	AAD	D-dimer	0.9000	0.9400	0.5680	0.5080	202	588	500	[27]
6	Xiao	2016	Serum	AAD	D-dimer	0.8910	0.9333	0.6833	0.6166	60	60	1435	[28]
7	Gorla	2017	Plasma	AAD	D-dimer	0.9100	0.9600	0.6320	0.5920	376	291	500	[29]
8	Gorla	2017	Plasma	AAD	D-dimer	0.9600	0.9900	0.6700	0.6600	159	72	500	[30]
9	Yoshimuta	2015	Plasma	AAD	D-dimer	NP	1.0000	0.9480	0.9480	9	1227	6900	[31]
10	Peng	2015	Serum	AAD	D-dimer	0.9300	0.8000	0.9021	0.7021	35	52	2110	[32]
11	Shao	2014	Plasma	AAD	D-dimer	0.8080	0.6970	0.7740	0.4710	89	279	320	[44]
12	Nazerian	2014	Venous blood	AAD	D-dimer	NP	0.9830	0.3590	0.3420	233	802	500	[40]
13	Okazaki	2014	Plasma	AAD	D-dimer	0.9000	0.8000	0.9780	0.7780	15	46	8700	[42]
14	Giachino	2013	Plasma	AAD	D-dimer	0.8700	0.9760	0.3280	0.3040	52	74	500	[37]
15	Ersel	2010	Serum	AAD	D-dimer	0.7640	0.9660	0.9730	0.9390	30	69	NP	[35]
16	Fan	2010	Plasma	AAD	D-dimer	0.8950	0.9910	0.4180	0.4090	107	136	260	[36]
17	Sbarouni	2007	Plasma	AAD	D-dimer	NP	0.9400	0.5900	0.5300	18	29	700	[43]
18	Ohlmann	2006	Plasma	AAD	D-dimer	0.8800	0.9900	0.3400	0.3300	94	94	400	[41]
19	Hazui	2005	Plasma	AAD	D-dimer	0.9780	0.9310	0.9310	0.8620	29	49	800	[38]
20	Akutsu	2005	Plasma	AAD	D-dimer	NP	1.0000	0.5400	0.5400	30	48	500	[33]
21	Eggebrecht	2004	Plasma	AAD	D-dimer	0.8650	1.0000	0.7300	0.7300	16	48	626	[34]
22	Weber	2003	NP	AAD	D-dimer	NP	1.0000	0.6857	0.6857	24	35	500	[45]

AUC, area under the curve of receiver operator characteristics. Sen, sensitivity. Spe, specificity. AAD, acute aortic dissection. AD, aortic dissection. NP, not report