Table 2.

Characteristics of studies about combined D-dimer and other biomarkers included in the analysis

No	Author	Year	Sample	Disease	Biomarker	AUC	Sen	Spe	Youden index	No. Case	No. Control	References
1	Yang	2020	Plasma	TAD	D-dimer + hs-CRP + ANGPTL8	0.9270	0.7950	0.9850	0.7800	78	72	[23]
2	Yang	2020	Plasma	TAD	D-dimer + ANGPTL8	0.9090	0.8330	0.8940	0.7270	78	72	[23]
3	Xiao	2016	Serum	AAD	Lumican + D-dimer	0.9620	0.8833	0.9500	0.8330	60	60	[28]
4	Giachino	2013	Plasma	AAD	log2MMP8 + D-dimer	0.8900	1.0000	0.1310	0.1310	52	74	[37]
5	He	2019	Plasma	AAD	SAA + D-dimer	0.9000	0.8480	0.9380	0.7860	63	87	[39]
6	Ma	2021	Serum	AAD	CP + D-dimer	0.7070	0.6360	0.9410	0.5770	102	85	[21]

AUC, area under the curve of receiver operator characteristics. Sen, sensitivity. Spe, specificity. AAD, acute aortic dissection