. Author manuscript; available in PMC: 2023 Oct 10.

Published in final edited form as: JACC Heart Fail. 2021 Jun 9;9(7):484–493. doi: 10.1016/j.jchf.2021.04.003

Table 4.

Multivariable-adjusted associations between categorical measures of obesity and subclinical myocardial injury with risk of HFpEF and HFrEF.

	HFpEF		HFrEF
	HR (95% CI)	P value	HR (95% CI)	P value
Referent group: Non-obese, no subclinical myocardial injury
Non-obese, subclinical myocardial injury	1.42 (0.82, 2.47)	0.21	1.87 (1.14, 3.06)	0.01
Obese, no subclinical myocardial injury	1.65 (1.03, 2.64)	0.04	0.93 (0.58, 1.50)	0.78
Obese, subclinical myocardial injury	2.79 (1.74, 4.46)	<0.001	2.20 (1.38, 3.51)	<0.001

Obesity refers to BMI ≥30 kg/m². Subclinical myocardial injury refers to hs-cTnI ≥6 ng/L in men and ≥4 ng/L in women. Model is adjusted for the following covariates: age, sex, history of hypertension, history of diabetes, systolic BP, HbA1c, history of CVD, eGFR, smoking status, log PA, obesity/injury groups.

Abbreviations: BMI, body mass index; BP, blood pressure; CVD, cardiovascular disease; eGFR, estimated glomerular filtration rate; HbA1c, glycated hemoglobin; HF, heart failure; HFpEF, heart failure with preserved ejection fraction; HFrEF, heart failure with reduced ejection fraction; PA, physical activity.