Fig. 3. Mechanisms shared by cancer and stem cells to exit quiescence and begin proliferation:

To re-enter the cell cycle both cancer and stem cells have to alter their transcriptional programs, activate metabolism, and increase protein translation. METTL family members play roles in all three of these processes, and some have overlapping roles in more than one. These roles are substrate-specific and are likely to expand as additional METTL family targets are identified.