Table 3.

Recommendations for all patients taking urate-lowering therapy (ULT)^*

Recommendation	PICO question	Certainty of evidence
For all patients taking ULT, we strongly recommend a treat-to-target strategy of ULT dose management that includes dose titration and subsequent dosing guided by serial SU values to achieve an SU target over a fixed, standard-dose ULT strategy.	13	Moderate
For all patients taking ULT, we strongly recommend continuing ULT to achieve and maintain an SU target of <6 mg/dl over no target.	14	High
For all patients taking ULT, we conditionally recommend delivery of an augmented protocol of ULT dose management by nonphysician providers to optimize the treat-to-target strategy that includes patient education, shared decision-making, and treat-to-target protocol.	8	Moderate
We conditionally recommend continuing ULT indefinitely over stopping ULT.	19	Very low
Strongly recommend Conditionally recommend Strongly recommend against Conditionally recommend against

^*PICO = population, intervention, comparator, outcomes; SU = serum urate.