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. 2023 Sep 27;12(11):e230108. doi: 10.1530/EC-23-0108

Table 1.

Available Connected Pen and Pen Caps.

Device – company Device features Dose tracking Dose calculating GLP-1 Connectivity and integration Mobile app features Insulin compatibility Availability
Available in the USA and internationally (FDA approved and CE marked)
InPen – Medtronic (21)

  • Reusable pen that lasts 1 year

  • Monitors insulin temperature

  • Bluetooth pairs to smartphone app

  • Tracks actual insulin dose and timing

 x x Integrated with Dexcom, Medtronic CGMs
View data via Insights Report or Medtronic’s Carelink portal

  • iOS and Android

  • Integrated bolus calculator

  • Manually long-acting insulin doses and can set up basal and bolus dose reminders

 NovoLog, Humalog, Fiasp
Cartridge only		 FDA-cleared for type 1 or type 2 diabetes
CE marked
InsulCheck Connect –Innovation Zed (34)

  • Reusable, with replaceable battery

  • Smart pen cap

 x N/A

  • Compatible with diabetes mobile apps

 Compatible with Lilly’s HumaPen Luxura and KwikPens; Novo Nordisk’s FlexPen, NovoPen 3, and NovoPen 4; and Sanofi Aventis CE marked
FDA-cleared class 1 medical device
InsulCheck DOSE –Innovation Zed (34)

  • Reusable, rechargeable with seven to ten day battery life

  • Smart pen cap

  • Captures temperature and mounting data

 x N/A

  • Compatible with diabetes mobile apps

 Compatible with Lilly’s HumaPen Luxura and KwikPens; Novo Nordisk’s FlexPen, NovoPen 3, and NovoPen 4; and Sanofi Aventis CE marked
FDA-cleared class 1 medical device
Mallya – Biocorp (24)

  • Reusable smart cap for disposable pens, lasts 2 years

  • Two-piece cap with one piece clipped to top of pen and second piece over the control dial/button

  • Pen cap USB rechargeable; needs recharge approximately once a month

  • Sends dose, time, and date to app via Bluetooth

  • Cap-specific versions for SoloStar, FlexPen, and KwikPen

 x x Data sharing partnership with DreaMed to send insulin dosing data to MDI/basal-only Advisor Pro clinical decision support system

  • iOS

  • Sends dose reminders and alerts

  • Records dose, time, and date

 SoloStar (LantusToujeo, Admelog, Apidra, Soliqua), KwikPen, FlexPen FDA cleared for type 1 or type 2 diabetes
CE marked
Tempo Smart Button and Pen – Eli Lilly (25)

  • Works with Lilly Tempo pens (Basaglar, Humalog, Lyumjev)

  • Reusable Tempo Smart Button attaches to top of disposable Tempo Pen for data transfer via Bluetooth

  • Tempo button battery lasts 8 months

  • Button for both basal and bolus insulin doses

  • Tracks insulin dose, timing, and type of insulin delivered

 x xa
Compatible with Dexcom CGMs or BGM
Data integration with Roche (mySugr), Glooko, myDiabby, Dexcom apps
Sync data with wearable devices (Fitbit, Garmin, Google Fit, Apple Health)
View data in Tempo Insights Portal

  • iOS and Android

  • Tracks insulin dose

  • Sends dosing reminders

  • Monitors carb intake (can take picture of food and estimates carbs) and fitness activities

  • App titrates basal, bolus, and basal + bolus

  • In the USA, private label iteration of Welldoc’s BlueStar app (titrates basal, bolus, and basal + bolus)

  • Shares data with HCPs through clinician hub Tempo Insights

 Tempo Pens Basaglar 100 units/mL, Humalog 100 units/mL, and Lyumjev 100 units/mL FDA cleared for type 1 or for type 2 diabetes
CE marked
Available in the USA only (FDA approved)
Bigfoot Unity – Bigfoot Biomedical (23)

  • Reusable smart cap for disposable and durable insulin pens

  • White-colored insulin pen caps fits over rapid-acting insulin pens; black-colored insulin pen caps fit over long-acting insulin pens

  • Rapid-acting pen cap uses data from Abbott’s FreeStyle Libre 2 CGM to generate dose recommendations shown on cap’s display; option to use blood glucose meter linked to an app to inform dose recommendations

  • Sends insulin dose data to Bluetooth-paired smartphone app

  • Track insulin dose time, temperature, and recommended dose

 xb x Integrated with Abbott FreeStyle Libre 2 (FSL 2)
View data in Bigfoot Clinic Hub Portal

  • iOS and Android

  • Real-time hypo alerts and can see glucose range/trends overtime from FSL 2

  • Notifies the user of potential missed doses

 Rapid-acting KwikPen Humalog (U-100 and U-200), Lispro, Lyumjev (U-100 and U-200); SoloSTAR: Apidra, Admelog; FlexTouch: Fiasp (U-100); FlexPen: NovoLog (U-100), ReliOn NovoLog (U-100), Aspart
Long-acting KwikPen: Basaglar; SoloSTAR: Lantus, Toujeo (U-300), Toujeo Max (U-300); FlexTouch: Tresiba (U-100 and U-200)		 FDA cleared for type 1 or type 2 diabetes
Available internationally only (CE marked)
ESYSTA – Emperra (35)

  • Reusable for 1 year

  • Smart pen displays last dose, automatic transfer of insulin doses

 x Beurer GL50 evo and GlucoCheck Gold BGMs

  • iOS and Android

 Lilly’s Kwikpen, Novo Nordisk’s Flextouch, and Sanofi’s Solostar CE marked
InsulClock – InsulClock (30) Reusable for 5 years. Battery charge lasts 3 days with 1.5 h of charge via USB
Smart cap tracking dose, time, and type of insulin
Monitors insulin storage temperature		 x Integrates with Dexcom CGMs iOS and Android
Allows for meal and exercise tracking
Monitors insulin storage temperature		 Lilly’s Kwikpen, Novo Nordisk’s Flextouch, and Sanofi’s Solostar CE marked
NovoPen 6 – Novo Nordisk (36)

  • Reusable pen; 800-dose memory, 5-year battery life

  • Last insulin dose and time of injection on end of pen

  • Compatible with both basal and bolus insulin

  • Adjustments of 1 U increments with 60 U max dose

  • NFC connectivity

 x Data integration with Abbott, Roche, Glooko, Dexcom apps

  • Connects to compatible iOS and android diabetes apps (Glooko, Abbott’s FreeStyle LibreLink, mySugr, Dexcom Clarity)

  • Sends insulin dose info to preferred diabetes app and shares with HCP

  • Local app integrators in select markets (Japan: Health2Sync, Arkray; France: myDiabby, Glooko XT; Denmark, UK, Switzerland, Ireland, France, Luxembourg, Malta: Hedia)

 Levemir, Xultophy, Tresiba, NovoLog, Fiasp
Cartridge only		 CE marked
NovoPen Echo Plus – Novo Nordisk (37)

  • Reusable pen; 800-dose memory, 5-year battery life

  • Last insulin dose and time of injection on end of pen

  • Compatible with both basal and bolus insulin

  • Adjustments 0f 0.5 U increments with 30 U max dose

  • NFC connectivity

 x Data integration with Abbott, Roche, Glooko, Dexcom apps

  • Connects to compatible iOS and android diabetes apps (Glooko, FreeStyle Abbott’s LibreLink, mySugr, Dexcom Clarity)

  • Sends insulin dose info to preferred diabetes app and shares with HCP

  • Local app integrators in select markets (Japan: Health2Sync, Arkray; France: myDiabby, Glooko XT; Denmark, UK, Switzerland, Ireland, France, Luxembourg, Malta: Hedia)

 Levemir, Tresiba, NovoLog, Fiasp
Cartridge only		 CE marked
YpsoMate On – Ypsomed (38)

  • Single use

  • Connected smart insulin pen with prefilled autoinjector

 x N/A

  • Bluetooth connectivity to Ypsomed mobile app

 Ypsomed Ypsomate insulin pens
Cartridge only		 CE marked
SmartPilot – Ypsomed (39)

  • Reusable, no charge required

  • Smart cap tracking dose, time, and authenticates insulin

  • Provides audio and visual feedback of dosing technique

 x N/A

  • Bluetooth connectivity to Ypsomed mobile app

 Ypsomed YpsoMate insulin pens
Cartridge only		 Not yet CE marked

aTitration feature only available in the USA; bOnly tracks that a dose was given, not the details of the actual dose. X, insulin device has insulin dose tracking and/or calculates insulin dose