Table 1.

Differential diagnosis of delayed puberty in addition to CDGP.

	Hypergonadotropic hypogonadism	Hypogonadotropic hypogonadism	Functional hypogonadotropic hypogonadism
Male	Klinefelter syndrome Congenital anorchia/testicular regression	Kallmann syndrome Combined pituitary hormone deficiency CNS: Tumors/infiltrative diseases Chemotherapy/Radiation therapy	Systemic illness e.g. (inflammatory bowel disease, celiac disease, anorexia nervosa, excessive exercise, chronic kidney disease, sickle cell disease and thalassemia, severe obesity, opioids); chronic stress
Female	Turner syndrome Premature ovarian insufficiency	Kallmann syndrome Combined pituitary hormone deficiency CNS: Tumors/infiltrative diseases Chemotherapy/Radiation therapy	Systemic illness e.g. (inflammatory bowel disease, celiac disease, anorexia nervosa, bulimia nervosa, excessive exercise, chronic kidney disease, sickle cell disease and thalassemia, opioids); chronic stress