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Anti‐oxidative mechanism of lycopene. Lycopene inhibits ROS generation and subsequent oxidative stress by inducing antioxidant enzymes (SOD, CAT, GSH, GSH‐Px, and GST) and limiting MDA level and lipid peroxidation (LPO). Lycopene also prevents ROS release by upregulating Nrf2‐mediated HO‐1 levels and inhibiting iNOS‐activated NO generation. In addition, lycopene prevents oxidative stress through upregulating total antioxidant capacity (TAC) and direct inhibition of 8‐OHdG, NOX4.
