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. 2023 Aug 31;11(10):5856–5872. doi: 10.1002/fsn3.3615

TABLE 1.

The antimicrobial activity of GA.

Compounds Strains Functions References
GA Escherichia coli Blocked the catalase activity, inhibition of biofilm formation by the effect on the pgaABCD genes expression Kang, Li, et al. (2018), Wang et al. (2018)
GA Klebsiella pneumoniae Disrupted membrane integrity, inhibited the growth and production of capsular polysaccharide Khorsandi et al. (2021)
GA Staphylococcus aureus Inhibited the biofilm formation by the effect on the expression of the ica operon Liu et al. (2017)
GA Shigella flexneri In the destroyed cell, the bacterial morphology inhibited biofilm formation by the effect on the expression of the mdoH gene and the OpgH protein Kang, Liu, et al. (2018)
Octyl gallate E. coli and S. aureus Destroying the cell wall, Penetration the cell, interacting with DNA, damaging the activity of the respiratory chain, increasing the production of ROS Shi et al. (2021)
GA‐grafted‐chitosans + ampicillin penicillin oxacillin MRSA Had synergic effects on bacteria, induced loss of membrane integrity, and released intracellular components Lee et al. (2014)
GA+ hydroxytyrosol E. coli S. pyogenes, K. Pneumoniae, S. aureus Inhibited the growth of bacteria and had a synergistic effect against all four strains Tafesh et al. (2011)
GA+ ceftiofur S. Typhimurium This compound had an additive effect on bacteria, inhibited the growth of plankton and bacterial biofilm, changed the morphology of bacteria, and inhibited the swimming and swarming motilities of bacterial Hossain, Park, Lee, et al. (2020)
GA+ thiamphenicol E. coli Altered bacterial morphology, synergistically inhibited the growth of plankton and bacterial biofilms Hossain, Park, Park, et al. (2020)
Au‐NP‐ GA P. shigelloides S. flexneri Destruction of membrane surface macromolecules Daduang et al. (2016)
GA‐ loaded – ZnO NPs MRSA Had strong antioxidant and antibiotic effects Lee et al. (2017)
GAGO MRSA The nanoformulation significantly increased the antibacterial activity of GA Shamsi et al. (2018)
GA‐g‐chitin‐glucan complex E. coli B. subtilis Had stronger antibacterial properties compared to the unmodified chitin‐glucan complex Singh et al. (2019)

Abbreviations: GA‐g‐chitin‐glucan, GA grafted chitin‐glucan complex; GAGO, GA Loaded Graphene Oxide; P. shigelloides, Plesiomonas shigelloides; S. flexneri, Shigella Flexner.