TABLE 3.

Comparison of methods used and MICs of antimicrobial agents tested against Legionella spp. in different studies

Mediuma	Inoculum (CFU/spot)	Incubation time (h)	MIC90, MIC90 range, or geometric mean MIC (μg/ml) for:					Reference
			Erythromycin	Rifampin	Ciprofloxacin	Levofloxacin	Dalfopristinquinupristin
BSYE	104/105	48	0.12	0.002/0.008	d.n.a.d	0.015/0.03	0.5	This study
BCYE	104	48	1	≤0.004	d.n.a.	0.125	d.n.a.	2e
BCYE	104	72	d.n.a.	0.03–0.125	d.n.a.	d.n.a.	d.n.a.	3e
LHRC-BYE	104	72	d.n.a.	0.00035–0.00075	d.n.a.	d.n.a.	d.n.a.	3e
BAM1	6 × 105	72	0.25b	d.n.a.	d.n.a.	d.n.a.	d.n.a.	4
BCYE	6 × 105	72	0.12b	d.n.a.	d.n.a.	d.n.a.	d.n.a.	4
BYE	6 × 105	72	0.12b	d.n.a.	d.n.a.	d.n.a.	d.n.a.	4
BCYE	105	48	1	0.008	2	d.n.a.	d.n.a.	6
BSYE	105	48	0.5	≤0.002	0.125	d.n.a.	d.n.a.	6
BYE	104	48	0.25–1c	≤0.004–0.008c	0.01–0.12c	d.n.a.	0.12–0.5c	10e
CYE	104/105	72	0.25/0.5	0.125/0.125	d.n.a.	d.n.a.	d.n.a.	15e
BCYE	104	96	≥2	0.5	2	d.n.a.	d.n.a.	17
BSYE	104	96	0.5	≤0.015	≤0.06	d.n.a.	d.n.a.	17
BSYE	106	48	0.5	0.008	0.06	d.n.a.	1	24e
BCYE	104	48	1	d.n.a.	1	0.5	d.n.a.	29e
BSYE	106	48	0.06	d.n.a.	0.015	0.015	d.n.a.	29e

^aAbbreviations: LHRC, lysed horse red cell; BYE, buffered yeast extract; BAM₁, buffered antibiotic medium no. 1; CYE, charcoal-yeast extract. 

^bGeometric mean MIC. 

^cMIC₉₀ range. 

^dd.n.a., data not available. 

^eData for L. pneumophila.