Cytotoxicity (IC₅₀) of tested compounds on different cell lines^ac.

Compound no.	In vitro cytotoxicity IC50b (μM)
	HePG2	HCT-116	MCF-7	PC3
DOX	4.50 ± 0.2	5.23 ± 0.3	4.17 ± 0.2	8.87 ± 0.6
3	39.72 ± 3.5	25.34 ± 3.8	24.07 ± 3.6	38.60 ± 4.3
4	29.64 ± 3.0	23.79 ± 3.5	20.35 ± 2.5	31.38 ± 3.8
5a	24.31 ± 2.6	14.11 ± 2.4	21.07 ± 2.3	34.76 ± 2.9
5b	12.89 ± 0.9	17.70 ± 1.4	17.22 ± 0.6	14.65 ± 1.8
5c	31.83 ± 2.1	44.06 ± 3.2	45.20 ± 2.0	41.34 ± 3.6
5d	6.94 ± 0.4	11.62 ± 1.0	5.60 ± 0.4	10.51 ± 1.3
6	10.11 ± 3.1	8.23 ± 3.3	7.61 ± 3.4	13.83 ± 3.8

^aThe data are expressed as the mean of three replicates ± standard deviation.

^bIC₅₀ (μM): 1–10 (very strong). 11–20 (strong). 21–50 (moderate). 51–100 (weak) and above 100 (non-cytotoxic).

^cDOX: doxorubicin.