Calculated physicochemical properties^a.

Compound no.	MW	n HD	n HA	Log P	Lipinski's rule	Log S	QED
3	270.15	1	5	2.581	Accepted	−4.048	0.672
4	359.17	1	6	3.551	Accepted	−4.453	0.358
5a	365.19	4	7	2.807	Accepted	−4.213	0.24
5b	415.2	4	7	3.715	Accepted	−4.814	0.189
5c	476.22	3	6	5.432	Accepted	−6.462	0.102
5d	424.17	3	6	4.451	Accepted	−5.031	0.243
6	419.17	2	10	4.926	Accepted	−6.068	0.402

^aWhere; MW, molecular weight; n_HA, number of hydrogen bond acceptor; n_HD, number of hydrogen bond donor; log S, logarithm of aqueous solubility value, log P, logarithm of the n-octanol/water distribution coefficient; QED, a measure of drug-likeness based on the concept of desirability.