The probable molecular targets for compounds 5d and 6.
| Compound no. | The probable molecular targets |
|---|---|
| 5d | PIK3CB (PI3-kinase p110-beta subunit) |
| PIK3CA (PI3-kinase p110-alpha subunit) | |
| F9 (coagulation factor IX) | |
| PPID (peptidyl-prolyl cis–trans isomerase D) | |
| MAOB (monoamine oxidase B) | |
| GSK3B (glycogen synthase kinase-3 beta) | |
| CHRM4 (muscarinic acetylcholine receptor M4) | |
| ITK (tyrosine-protein kinase ITK/TSK) | |
| MMP13 (matrix metalloproteinase 13) | |
| ADORA1 (adenosine A1 receptor)a | |
| ADORA3 (adenosine A3 receptor) | |
| ABL1 (tyrosine-protein kinase ABL) | |
| GABRA2 (GABA receptor alpha-2 subunit) | |
| STK17B (serine/threonine-protein kinase 17B) | |
| STK17A (serine/threonine-protein kinase 17A) | |
| 6 | EDNRA/B (endothelin receptor ET-A/B) |
| SCN9A (sodium channel protein type IX alpha subunit) | |
| TBXA2R (thromboxane A2 receptor) | |
| EPHX1 (epoxide hydrolase 1) | |
| AURKA/B (serine/threonine-protein kinase Aurora-A/B) | |
| MAPK8 (c-Jun N-terminal kinase 1) | |
| MAPK10 (c-Jun N-terminal kinase 3) | |
| JAK1/2 (tyrosine-protein kinase JAK1/2) | |
| PTGS2 (cyclooxygenase-2) | |
| ESR2 (estrogen receptor beta) | |
| IMPDH2 (inosine-5′-monophosphate dehydrogenase 2) | |
| ADORA1 (adenosine A1 receptor)a | |
a
The common probable molecular target for compounds 5d and 6.