TABLE 6.
Five-y posttransplant c-statistic values for the full and abbreviated iBOX for CNI and CNI-free subjects at 1 year posttransplant in the validation datasets.
| Maintenance IST-based regimen | c-statistic (SE) | Observed graft loss events | Predicted graft loss events | p |
|---|---|---|---|---|
| Full iBOX | ||||
| CNI (TAC, CSA) n = 1045 | 0.82 (0.04) [TAC 0.86 (0.05), CSA 0.77 (0.05)] | 50 | 51.6 | .82 |
| CNI-free (mTORi, BELA) n = 456 | 0.75 (0.08) a | 13 | 16.6 | .38 |
| Abbreviated iBOX | ||||
| CNI (TAC, CSA) n = 1124 | 0.79 (0.04) [TAC 0.81 (0.05), CSA 0.77 (0.05)] | 61 | 58.9 | .78 |
| CNI-free (mTORI, BELA) n = 587 | 0.73 (0.07) a | 17 | 23.4 | .26 |
BELA, belatacept; CNI, calcineurin inhibitor; CSA, cyclosporine; mTORi, mammalian target of rapamycin signal inhibitor; SE, standard error; TAC, tacrolimus.
a
The mTORi group only had 38 subjects with no graft loss events, so no breakdown of c-statistic by treatment was performed for the CNI-free group.
A p-value of <0.05 would indicate a significant difference between the expected number of graft loss events as predicted by the iBOX versus the actual number of graft loss events.