TABLE 8.
C-statistics for each validation dataset as parameters are removed in the iBOX with all parameters (“full”), without biopsy (“abbreviated”), without biopsy and DSA (“only eGFR and proteinuria”), and without biopsy, DSA, and proteinuria (“only eGFR”).
| Dataset | c-statistic (SE) at 1 year posttransplant | |||
|---|---|---|---|---|
| Full iBOX | Abbreviated iBOX | iBOX with only eGFR and proteinuria | iBOX with only eGFR | |
| Mayo Clinic Rochester | 0.93 (0.03) | 0.84 (0.03) | 0.80 (0.04) | 0.75 (0.04) |
| Helsinki University Hospital | 0.78 (0.06) | 0.77 (0.06) | 0.76 (0.06) | 0.74 (0.06) |
| BENEFIT RCT | 0.70 (0.09) | 0.70 (0.08) | 0.69 (0.08) | 0.69 (0.08) |
| BENEFIT-EXT RCT | 0.81 (0.07) | 0.78 (0.06) | 0.78 (0.06) | 0.78 (0.06) |
eGFR, estimated glomerular filtration rate; DSA, donor-specific antibody; RCT, randomized controlled trial; SE, standard error.
Bold text highlights c-statistics <0.7.