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. 2023 Oct 6;16:4413–4423. doi: 10.2147/JIR.S422342

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© 2023 Yu et al.

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Andrographolide (AD) enhanced the phagocytic and bactericidal activities of peritoneal macrophages in mice with cecal ligation and puncture (CLP)-induced sepsis (n = 8). Peritoneal lavage fluid was obtained 24 and 48 h after CLP surgery. (A) Cells were stained for macrophage markers (CD11b+F4/80+) and assessed for phagocytic capacity as described in Section 2. CD86 and F4/80 double-positive cells indicate M1-type macrophages. (B) Cells were stained for macrophage surface markers (CD11b+F4/80+) and intracellular cytokine antibodies for inducible nitric oxide synthase or tumor necrosis factor (TNF)-α. All values are shown as means ± SEM. *P < 0.05 vs CLP group; **P < 0.01 vs CLP group. Each group had eight mice.