Table 2.
Main characteristics of the cohort studies included in the meta-analysis of prevalent CAD in hidradenitis suppurative
| Miller et al.[23] | Ward et al.[24] | Hua et al.[25] | |
|---|---|---|---|
| Country | Denmark | United States | United States |
| Study design | Retrospective cohort | Retrospective cohort | Retrospective cohort |
| Year of publication | 2018 | 2019 | 2021 |
| Total number of participants | Patients with TB: 2,283 Comparators: 6,849 | Patient with HS: 5,046 Comparators: 25,827 | Patient with HS: 13,667 Comparators: 136,670 |
| Recruitment of participants | Patients with HS were identified from the database of the General Suburban Population Study (GESUS) Comparators without HS were the rest of the participants of the survey who did not have HS | Patients with HS were identified from the database of the Duke University Medical Center Comparators without HS were randomly selected from the same database | Patients with HS were identified from the Clinformatics Data Mart database which contained health information of 77 million patients with commercially insured and Medicare coverage from 2003 to June 2019 Comparators without HS were randomly selected from the same database at 1:10 ratio. They were sex, age and race matched to cases. |
| Diagnosis of HS | Self-reported through health questionnaire | Presence of ICD codes for HS in the database | Presence of ICD codes for HS in the database at least twice |
| Diagnosis of CAD | Self-reported through health questionnaire | Presence of ICD codes for CAD in the database | Presence of ICD codes for MI in the database |
| Average age of participants (years) | NA | N/A | Cases with HS: 40.7 Comparator without HS: 40.7 |
| Percentage of female | NA | N/A | Cases with HS: 73.6 Comparator without HS: 73.6 |
| Variables adjusted in multivariate analysis | Age, sex, smoking and metabolic syndrome | Obesity, HTN, hyperlipidemia, renal disease, VTE, metabolic syndrome and DM | Obesity and smoking |
CAD=Coronary artery disease, DM=Diabetes mellitus, HS=Hidradenitis suppurativa, HTN=Hypertension, ICD=International classification of diseases, MI=Myocardial infarction, N/A=not available, VTE=Venous thromboembolism