TABLE 4.

Correlation between histopathologic and serologic results and efficacy of therapy in eradicating H. pylori from the gastric mucosa of infected gnotobiotic piglets

Treatment group or infection status	No. of piglets	Gastric inflammatory scorea	Serology resultb
			IgG	IgM	IgA
Treatment
None (vehicle controls)	3	5.3 ± 3.2	0.75 ± 0.26	0.57 ± 0.10	0.57 ± 0.39
Triple therapyc	6	4.7 ± 2.7 (NS)d	0.75 ± 0.16	0.39 ± 0.14	0.29 ± 0.12
Bismuth subsalicylatee	8	4.3 ± 1.8 (NS)	0.88 ± 0.24	0.61 ± 0.15	0.40 ± 0.29
Status of infection (regardless of treatment)
Present	9	5.2 ± 1.9	0.90 ± 0.27	0.64 ± 0.10	0.50 ± 0.31
Absent	8	4.4 ± 2.3 (NS)	0.71 ± 0.16	0.40 ± 0.12f	0.26 ± 0.12

^aSum of inflammatory scores (0 to 3; total of 12 possible) from the four regions (cardia, fundus, antrum, and pylorus) examined. Histopathologic data are expressed as the mean ± standard deviation score. 

^bSerologic data are expressed as mean ± standard deviation optical density at 450 nm. 

^cTriple therapy consisted of bismuth subsalicylate (5.7 mg/kg QID), metronidazole (4.4 mg/kg QID), and amoxicillin (6.8 mg/kg QID). 

^dNS, not statistically significant. 

^eBismuth subsalicylate (5.7 mg/kg QID) was used alone. 

^fStatistically significant (versus presence of infection) with a P value of <0.05.