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. Author manuscript; available in PMC: 2023 Oct 10.
Published in final edited form as: Ann Rheum Dis. 2021 Nov 17;81(3):406–415. doi: 10.1136/annrheumdis-2021-220578

Table 2:

HLA-DRB1*11:01 is Still’s-associated in the Still’s-DRESS cohort1

HLA allele Ancestry Still’s-DRESS Still’s controls INCHARGE Still’s (sJIA) INCHARGE healthy controls P value OR (95% CI)
DRB1*11:01 European vs 4/14 (29%) 103/550 (19%) 0.43
European INCHARGE 2/19 (10%) 0.36
313/3279 (10%) 0.095 3.7 (1.1–11.9)2
DRB1*11:01 Self-ID White vs European INCHARGE 7/35 (20%) 103/550 (19%) 0.051
2/19 (10%) 0.46
313/3279 (10%) 0.01 2.3 (1.0–5.2)2
DRB1*15:01 European 130/550 (24%) 822/3279 (25%) 0.59

P value, by logistic regression with sex as a covariate for INCHARGE comparisons; OR (95% CI), Odds ratio and 95% confidence interval; sJIA, systemic juvenile idiopathic arthritis; DRESS, Drug reaction with eosinophilia and systemic symptoms classified per RegiSCAR20; INCHARGE, International Childhood Arthritis Genetics Consortium13; European, Still’s-DRESS cases were ancestry-matched by PCA to Still’s (sJIA) INCHARGE

1

Additional information is provided in tables S1a–b and S4a–b.

2

Results are consistent with published data from INCHARGE consortium study of HLA association with sJIA.18 Drug exposure in INCHARGE sJIA subjects is unknown.