Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2023 Oct 10;14:6332. doi: 10.1038/s41467-023-41828-z

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Fig. 5 — A, B Percent fold change growth of cell-derived tumors (CDXs) from H1792 or A549 cells treated with indicated drugs (Trametinib: 1 mg/kg; Midostaurin: 25 mg/kg). N = 8 tumors per group in Rag2^-/-; Il2γr^-/- mice (data: mean +/− SEM; test: Kruskal-Wallis, Dunn’s adjustment). C, D Waterfall plots of tumors from (A) and (B) at the last day of experiment. E Percent fold change of Tram-resistant (TR) H1792 CDXs treated with indicated drugs (Trametinib: 1 mg/kg; Midostaurin: 25 mg/kg). N = 8 tumors per group in Rag2^-/-; Il2γr^-/- mice (data: mean +/− SEM; test: Mann–Whitney). F Waterfall plot of tumors from (E) at the last day of experiment. G, H Percent fold change of CDXs from H1792 (G) or H358 (H) treated with indicated drugs. 30 mg/kg (H1792) and 10 mg/kg (H358); Mido: 25 mg/kg. N: 14 (ctrl) and 12 (Soto, Mido and Combo) tumors in Rag2^-/-; Il2γr^-/- mice data: mean +/− SEM; test: one-way ANOVA, Tukey’s adjustment). I, J Waterfall plot of tumors in (G) and (H) at the last day of experiment. K Percent fold change growth of Soto-resistant (SR) H358 CDXs treated with indicated drugs (Soto: 10 mg/kg; Mido: 25 mg/kg). N: 10 tumors per group in Rag2^-/-; Il2γr^-/- mice (data: mean +/− SEM; test: t-test). L Waterfall plot of tumors from (K) at the last day of experiment.