Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2023 Oct 10;14:6332. doi: 10.1038/s41467-023-41828-z

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Fig. 6 — A Waterfall plot of lung tumors from the KrasG12C driven model (Kras^FSFG12C; Trp53^FRT/FRT mice) treated with the indicated drugs at day 28. N: number of tumors per group. Soto: 100 mg/kg; Mido: 25 mg/kg (test: Kruskal–Wallis, Dunn’s adjustment -all comparisons-; t-test -Soto vs combo-). B Waterfall plot graph of lung tumors from Kras^FSFG12C; Trp53^FRT/FRT mice at day 42 of treatment. *: units correspond to tumor volume change at day 28. N: number of tumors per group. Soto: 100 mg/kg; Mido: 25 mg/kg (test: Mann–Whitney). C Representative microCT images of lung tumors from Kras^FSFG12C; Trp53^FRT/FRT mice at different days of treatment. D Quantification of CD8 staining in tumors from T1-derived xenografts in F1 C57BL/6 x 129S4/Sv mice (7-day treatment). N: 10 tumor sections (ctrl and Mido); n: 6 tumor sections (Soto and Combo). Soto: 30 mg/Kg; Mido: 25 mg/kg (data: mean +/− SEM; test: one-way ANOVA, Tukey’s adjustment). E Immunohistochemistry images of tumors in (D) stained for CD8. Scale bar: 100 µM.