Fig. 4.

Integrative Genomics Viewer data show the reads corresponding to SMAD4::DCC fusion in LGASC and LNMSC. In intron 4 of the SMAD4 gene (position on a chromosome is 48,579,729), the red arrow points to the reads having soft-clipping bases. Supplementary alignments of these reads start from position 50,300,003, corresponding to DCC intron 3. The upper part represents LNMSC and the lower part LGASC. Only one corresponding read was identified in LGASC. LGASC, low-grade adenosquamous carcinoma; LNMSC, lymph node metastasis consisting of high-grade metaplastic carcinoma of the breast with a predominant metaplastic squamous cell carcinoma component