Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2023 Sep 27;10:1236617. doi: 10.3389/fmolb.2023.1236617

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2023 Shah and Woo.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

The epitope mapping and escape of BA.5, BQ.1.1, and XBB.1.5 subvariants from R40-1C8. (A) The epitope residues on RBD are predicted through DiscoTope (green color cartoon representation) and Molecular Operating Environment (MOE, Cyan color). The surface maps (colored according to chains) shows that R40-1C8 does not compete with Bebtelovimab. (B) Mutations in the RBD region of Spike protein of SARS-CoV-2 Omicron variants and their effect on the interface contacts with respect to R40-1C8. Mutations [including Phe(F)486Val(V)] at the interface are indicated with stick and circles. (C) Changes in the binding free energy of R40-1C8 bound to the SARS-CoV-2 variants. (D) Changes in the number of Hydrogen bonds between R40-1G8 and respective variants.