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. 2023 Sep 27;10:1236617. doi: 10.3389/fmolb.2023.1236617

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Copyright © 2023 Shah and Woo.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The escape of Omicron BQ.1.1 and XBB.1.5 from Bebtelovimab. (A) Mutations in the RBD region of Spike protein of SARS-CoV-2 Omicron variants and their effect on the interface contacts with respect to Bebtelovimab. (B) Mutations in both BQ.1.1 and XBB.1.5 abolish the Bebtelovimab interface. (C) Changes in the binding free energy (BFE, calculated through MMGBSA). Bebtelovimab loses its binding affinity against both new variants.